研究方向侧重于分子同位素体的测量和理论模拟，以追踪天然物质的来源和化学反应。正在开展的研究方向包括：

1）天然氢气的来源和成藏

2）分子层面的干酪根–石油–天然气转化过程

3）有机物同位素指示生物过程

国家自然科学基金面上项目, 2025–2029，主持

国家青年人才项目海外，2024–2027，主持

南京大学人才启动经费，2024–2027，主持

********专项课题，2025–2028，子课题负责人

合作创新团队项目，2025–2027，骨干

国家重点研发计划，2025–2029，骨干

# First-authored:

Xie, H., Lloyd, M. K., Baczynski, A. A., Diefendorf, A. F., & Freeman, K. H. (2026). Temperature Sensitivity of Leaf Wax n‐Alkane Carbon Isotopes: Mechanisms and Implications for Terrestrial Paleoclimates. Geophysical Research Letters, 53(3).

Xie, H., Formolo, M., & Eiler, J. (2024). Theoretical and experimental constraints on hydrogen isotope equilibrium in C1-C5 alkanes. Geochimica et Cosmochimica Acta, 386, 63-73,

Xie, H., Formolo, M., & Eiler, J. (2022). Predicting isotopologue abundances in the products of organic catagenesis with a kinetic Monte-Carlo model. Geochimica et Cosmochimica Acta, 327, 200-228.

Xie, H., Dong, G., Formolo, M., Lawson, M., Liu, J., Cong, F., ... & Eiler, J. (2021). The evolution of intra-and inter-molecular isotope equilibria in natural gases with thermal maturation. Geochimica et Cosmochimica Acta, 307, 22-41.

Xie, H., Ponton, C., Formolo, M. J., Lawson, M., Ellis, G. S., Lewan, M. D., ... & Eiler, J. M. (2020). Position-specific distribution of hydrogen isotopes in natural propane: Effects of thermal cracking, equilibration and biodegradation. Geochimica et Cosmochimica Acta, 290, 235-256.

Xie, H., Ponton, C., Formolo, M. J., Lawson, M., Peterson, B. K., Lloyd, M. K., ... & Eiler, J. M. (2018). Position-specific hydrogen isotope equilibrium in propane. Geochimica et Cosmochimica Acta, 238, 193-207.

# Other:

McIntosh, O. M., Baczynski, A. A., Matney, M., McLain, H. L., Farnsworth, K. K., Dworkin, J. P., ... & Freeman, K. H. (2025). Stable Nitrogen Isotope Analysis of Amino Acids by Orbitrap Mass Spectrometry: Application for Extraterrestrial Samples. Rapid Communications in Mass Spectrometry, 39(23), e10127.

Sato, Y. J., Baczynski, A. A., Xie, H., Gilbert, A., & Freeman, K. H. (2025). Molecular Average and Intramolecular δ13C Measurements of Pyruvic Acid and Acetic Acid Using Gas Chromatography Orbitrap Mass Spectrometry (GC Orbitrap-MS). Analytical Chemistry, 97(35), 19047-19056.

Li, X., Xie, H., Birdwell, J. E., McGovern, G. P., & Horita, J. (2023). Intramolecular carbon isotope geochemistry of butane isomers from laboratory maturation and Monte-Carlo simulations of kerogen types I, II, and III. Geochimica et Cosmochimica Acta, 360, 57-67.

Mangenot, X., Xie, H., Crémière, A., Giunta, T., Lilley, M., Sissmann, O., ... & Eiler, J. (2023). 2H-2H clumping in molecular hydrogen method and preliminary results. Chemical Geology, 621, 121278.

Tyne, R. L., Barry, P. H., Lawson, M., Byrne, D. J., Warr, O., Xie, H., ... & Ballentine, C. J. (2021). Rapid microbial methanogenesis during CO2 storage in hydrocarbon reservoirs. Nature, 600(7890), 670-674.

Shuai, Y., Xie, H., Zhang, S., Zhang, Y., & Eiler, J. M. (2021). Recognizing the pathways of microbial methanogenesis through methane isotopologues in the subsurface biosphere. Earth and Planetary Science Letters, 566, 116960.

Dong, G., Xie, H., Formolo, M., Lawson, M., Sessions, A., & Eiler, J. (2021). Clumped isotope effects of thermogenic methane formation: insights from pyrolysis of hydrocarbons. Geochimica et Cosmochimica Acta, 303, 159-183.

Jautzy, J. J., Douglas, P. M., Xie, H., Eiler, J. M., & Clark, I. D. (2021). CH4 isotopic ordering records ultra-slow hydrocarbon biodegradation in the deep subsurface. Earth and Planetary Science Letters, 562, 116841.

Thiagarajan, N., Xie, H., Ponton, C., Kitchen, N., Peterson, B., Lawson, M., ... & Eiler, J. (2020). Isotopic evidence for quasi-equilibrium chemistry in thermally mature natural gases. Proceedings of the National Academy of Sciences, 117(8), 3989-3995.

Eiler, J. M., Clog, M., Lawson, M., Lloyd, M., Piasecki, A., Ponton, C., & Xie, H. (2018). The isotopic structures of geological organic compounds. Geological Society, London, Special Publications, 468(1), 53-81.

国家高层次青年人才（海外）

国家优秀自费留学生奖学金

Agouron Insitute Geobiology Postdoctoral Fellowship